Changes of the glutathione redox system during the weaning transition in piglets, in relation to small intestinal morphology and barrier function

Table 2 Effect of birth weight (n = 90), weaning treatment (n = 60) and days post-weaning (n = 36), and their interaction (n = 12-30), on oxidative stress biomarkers in weaned piglets

	Birth weight (Biw)		Weaning treatment (WT)			Days post-weaning (DPW)					SEM	P-value
	LBW	NBW	3d3w	3w	4w	d0	d2	d5	d12	d28		BiW	WT	DPW	BiW× DPW	WT× DPW	BiW× WT
ORAC, μmol trolox eq./mL
PLA	23.4	23.5	22.6^a	24.4^b	23.3^ab	24.1^y	24.6^z	24.2^yz	22.7^xy	21.7^x	0.2	0.901	<0.001	<0.001	0.536	0.252	0.640
MDA, nmol/mg prot.
PLA*	10.9	10.7	11.1	10.9	10.5	11.6^z	11.0^yz	10.2^y	10.0^y	11.3^z	0.1	0.386	0.127	<0.001	0.713	0.661	0.306
DUO	299	285	288	304	284	261^y	283^y	287^yz	296^yz	332^z	6	0.210	0.337	<0.001	0.972	0.040	0.782
JEJ	334	351	312^a	371^b	343^ab	408^z	416^z	282^y	296^y	310^y	8	0.301	0.016	<0.001	0.788	<0.001	0.402
LIV	634	650	648	640	637	646^y	504^x	632^y	675^yz	754^z	12	0.502	0.926	<0.001	0.825	0.005	0.343

Birth weight (Biw), weaning treatment (WT), day post-weaning (DPW), oxygen radical scavenging activity (ORAC), malondialdehyde (MDA), blood plasma (PLA), duodenal mucosa (DUO), distal jejunal mucosa (JEJ), liver tissue (LIV). Piglets were either weaned at three weeks of age (3w), four weeks of age (4w), or separated from the sow at 3d of age and fed a milk replacer until weaning at 3w of age (3d3w), and either had a low birth weight or normal birth weight (NBW). ^a,b Within a row, means without a common superscript differ for the effect of weaning treatment (WT: P ≤ 0.05). ^x,y,z Within a row, means without a common superscript differ for the effect of days post-weaning (DPW: P ≤ 0.05). ^* Expressed in nmol/mL plasma

ISSN: 2049-1891