Table 2 Uniquely regulated GO-biological processes of 2D organoids exposed to various protein sources. List of biological processes as analyzed in GeneAnalytics using the differentially expressed genes compared to medium control (MC)
From: Effects of undigested protein-rich ingredients on polarised small intestinal organoid monolayers
| Sl No. | Biological processes modulated in treatments compared to MC | Putative regulation of biological process |
|---|---|---|
| CAS | ||
| 1 | Glutathione metabolic process | Down |
| 2 | Notochord development | Up |
| 3 | Microtubule-based movement | Up |
| 4 | Glutathione derivative biosynthetic process | Down |
| 5 | Cellular detoxification of nitrogen compound | Down |
| SBM | ||
| 1 | Phosphatidylcholine biosynthetic process | Down |
| 2 | Triglyceride homeostasis | Down |
| 3 | Drug metabolic process | Down |
| 4 | Type I interferon signaling pathway | Up |
| 5 | Retinol metabolic process | Down |
| 6 | Hexose transport | Down |
| 7 | Lipoprotein metabolic process | Down |
| 8 | Retinoid metabolic process | Down |
| SDPP | ||
| 1 | Nucleosome assembly | Up |
| 2 | Positive regulation of apoptotic process | Up |
| 3 | Positive regulation of cell migration | Up |
| 4 | Response to wounding | Up |
| 5 | Wound healing, spreading of cells | Up |
| 6 | Negative regulation of cell cycle | Up |
| 7 | DNA replication-independent nucleosome assembly | Up |
| 8 | Cellular response to organic cyclic compound | Up |
| 9 | Angiogenesis | Up |
| 10 | Telomere organization | Up |
| 11 | Response to virus | Up |
| 12 | Cytokinesis | Up |
| 13 | DNA replication-dependent nucleosome assembly | Up |
| 14 | DNA-templated transcription, initiation | Up |
| 15 | Response to hypoxia | Up |
| 16 | Positive regulation of fever generation | Up |
| 17 | Mitotic spindle midzone assembly | Up |
| 18 | Platelet degranulation | Up |
| 19 | Positive regulation of cytokinesis | Up |
| 20 | Chromatin silencing at RDNA | Up |
| 21 | Protein stabilization | Up |
| 22 | Protein localization to kinetochore | Up |
| 23 | Omega-hydroxylase P450 pathway | Up |
| 24 | Positive regulation of protein localization to nucleus | Up |
| YMW | ||
| 1 | Cholesterol biosynthetic process | Down |
| 2 | Steroid metabolic process | Down |
| 3 | Response to drug | Down |
| 4 | Oxidation-reduction process | Up |
| 5 | Transmembrane transport | Down |
| 6 | Isoprenoid biosynthetic process | Down |
| 7 | Very long-chain fatty acid metabolic process | Down |
| 8 | CDP-choline pathway | Down |
| 9 | Long-chain fatty acid metabolic process | Down |
| 10 | Steroid hormone mediated signaling pathway | Down |
| 11 | Response to gamma radiation | Up |